Assurity Plus Spot On 4.0 ml for Dogs – Complete Guide to Uses, Dosage, and Safety

Assurity Plus Spot On 4.0 ml for Dogs is a potent, easy-to-apply topical treatment specifically formulated for large dogs weighing over 25 kg. Designed to protect against external parasites like fleas, ticks, and lice, this solution combines two powerful ingredients: Imidacloprid and Permethrin. This blog provides an in-depth look at its indications, usage instructions, dosage, safety, and more.

Assurity Plus Spot On 4.0 ml Explained

Assurity Plus Spot On is a monthly flea and tick control solution that works by killing and repelling ectoparasites.

Key Ingredients:

• Imidacloprid (10%) – A neonicotinoid insecticide that disrupts the nervous system of parasites.

Target Parasites:

• Adult fleas (Ctenocephalides felis)
• Flea larvae
• Ticks (Rhipicephalus, Dermacentor, Ixodes species)
• Biting lice (Trichodectes canis)

Indications: When to Use Assurity Plus Spot On 4.0 ml for Dogs

Assurity Plus Spot On 4.0 ml is a veterinary-grade, topical ectoparasiticide specially formulated for large breed dogs weighing between 25–40 kg. It is indicated for both the treatment and prevention of infestations caused by fleas, ticks, and biting lice. This section helps you understand exactly when and why to use this product for your dog.

Primary Indications

1. Flea Infestations (Ctenocephalides felis)

• Quickly kills adult fleas within 12–24 hours.
• Interrupts the flea life cycle by preventing egg and larval development.
• Ideal for use in dogs exposed to high flea burden environments, such as kennels, dog parks, or multi-pet households.

2. Tick Infestations (Rhipicephalus, Dermacentor, Ixodes spp.)

• Prevents tick attachment and feeding through repellency (anti-feeding effect).
  • Lyme disease
  • Ehrlichiosis
  • Babesiosis
• Use in wooded, grassy, or rural environments with known tick populations.

3. Lice Infestations (Trichodectes canis)

• Eliminates biting lice, which cause skin irritation and discomfort.
• Suitable for dogs recently rescued or adopted from shelters or high-risk environments.

Preventive Indications (Monthly Use)

Even if no active infestation is present, Assurity Plus Spot On 4.0 ml is recommended as a preventive measure in the following scenarios:

Routine Parasite Prevention

• Monthly use keeps your dog protected year-round, especially in tropical, humid, or warm climates where parasites are active continuously.

 Flea Allergy Dermatitis (FAD) Management

• Dogs allergic to flea saliva benefit from ongoing flea prevention to avoid flare-ups and skin lesions.

 Multi-Pet Households

• Prevents cross-infestation from untreated animals in the same home.

 Outdoor and Active Dogs

• Dogs that frequently visit parks, forests, or farms are at higher risk of parasite exposure.

Traveling or Boarding

• Before sending your dog to kennels or traveling to endemic regions, applying Assurity Plus offers proactive protection.

Veterinary Use Scenarios

Veterinarians may recommend Assurity Plus Spot On 4.0 ml in cases involving:

• Recurrent ectoparasite infestations unresponsive to shampoos or collars
• Long-term flea control as part of a comprehensive dermatological treatment plan
• Post-treatment care following tick removal or infestation-related illness
• Combination therapy with dewormers or internal parasite control measures

Benefits of Assurity Plus Spot On 4.0 ml

• Broad-Spectrum Protection: Covers multiple parasites.
• Fast Acting: Starts killing fleas within 12 hours.
• Repellency Effect: Prevents ticks from attaching.
• Long-Lasting: One dose lasts up to 4 weeks.
• Waterproof: Remains effective even after bathing or swimming.

Dosing Recommendations and Step-by-Step Application

Correct dosing and application of Assurity Plus Spot On 4.0 ml are essential to ensure its effectiveness in protecting large dogs from fleas, ticks, and lice. The product is designed for dogs weighing between 25 kg and 40 kg, and it must be used exactly as directed for safe and optimal results.

Dosing Recommendations

 Each pipette contains a pre-measured 4.0 ml dose suitable for large breed dogs. Do not divide or combine doses unless specifically advised by a veterinarian.

Dosage Chart

Note: For dogs over 40 kg, consult your veterinarian for an appropriate combination of pipettes.

Step-by-Step Application Instructions

To ensure full absorption and parasite control, follow these directions carefully:

 1: Prepare the Pipette

• Remove the pipette from the foil pouch.
• Hold it upright and snap off the tip to open.

 2: Choose Application Site

• This location prevents the dog from licking the product and ensures safe absorption.

 3: Apply the Product

• Squeeze the entire contents of the pipette onto one or more spots along the dog’s back (especially for long-haired dogs, consider spreading the application along 2–3 points).

4: Let It Absorb

• Do not massage or rub the liquid into the skin.
• Allow the product to air dry naturally.
• Prevent your dog from getting wet (bathing, swimming, rain) for at least 48 hours.

Aftercare and Monitoring

• Keep treated dogs away from children and other pets until the application site is dry.
• Wash your hands thoroughly after applying.
• Monitor for any signs of irritation or adverse effects.
• Resume regular activities (grooming, bathing, playing) after the product has dried completely.

Important Reminders

• Do not split doses between pets or use leftover product.
• Never use on cats — permethrin is toxic to felines.
• If your dog shows signs of a reaction (e.g., drooling, trembling, skin redness), contact your veterinarian immediately.

Handling Precautions and Contraindications

Using Assurity Plus Spot On 4.0 ml responsibly ensures not only effective parasite protection but also the safety and well-being of your dog. Below are the essential safety measures and warnings every pet parent should follow:

For Dogs Only – Not for Use on Cats or Other Animals

• Permethrin, a key ingredient in this product, is highly toxic to cats and can cause serious or fatal reactions.
• Never use this product on cats, rabbits, or other non-canine animals.
• Keep treated dogs separated from cats for at least 24–48 hours after application.

Application Site Precautions

• Apply only to intact, healthy skin.
• Do not apply on wounds, irritated skin, or mucous membranes.
• If accidental eye or skin contact occurs, rinse thoroughly with water and seek veterinary advice if irritation persists.

Age and Weight Restrictions

• Use only on dogs weighing over 25 kg.
• For dogs under 25 kg, use the appropriate Assurity Plus dosage variant.

Prevent Ingestion

• Ensure the dog cannot lick the application site.
• If accidental ingestion occurs, consult a veterinarian immediately.

Water Exposure

• Do not bathe or allow swimming for 48 hours after application to ensure maximum efficacy.
• The product is waterproof once dry, but frequent bathing may reduce residual effectiveness.

Possible Side Effects

Most dogs tolerate Assurity Plus Spot On well. However, observe your pet for any signs of sensitivity, especially after the first dose.

Mild & Common Reactions:

• Temporary skin irritation (redness, itching, or slight burning sensation)
• Hair loss at application site

Rare & Serious Reactions:

• Vomiting or drooling
• Lethargy or restlessness
• Muscle tremors or incoordination

Use with Other Medications

• If your dog is on other medications or has a history of allergies, consult your vet before use.
• Do not combine with other topical treatments unless directed by a veterinary professional.

Scientific Evidence and Effectiveness of Assurity Plus Spot On 4.0 ml for Dogs

The effectiveness of Assurity Plus Spot On 4.0 ml is backed by scientific research and field studies that validate its ability to control and prevent infestations of fleas, ticks, and lice in dogs. Its active ingredients—Imidacloprid (10%) and Permethrin (50%)—work synergistically to deliver fast-acting, broad-spectrum protection.

Active Ingredient Mechanism

1. Imidacloprid:

• A neonicotinoid insecticide that binds to nicotinic acetylcholine receptors in the nervous system of insects.
• Causes paralysis and death in fleas and lice by disrupting nerve signal transmission.
• Provides adulticidal activity and inhibits flea reproduction by affecting larvae.

2. Permethrin:

• A synthetic pyrethroid with both insecticidal and acaricidal properties.
• Acts as a contact repellent and neurotoxin to ticks and other ectoparasites.
• Prevents tick attachment and feeding, reducing the risk of disease transmission such as canine ehrlichiosis, babesiosis, and Lyme disease.

Clinical Studies & Results

Several controlled trials have evaluated the effectiveness of Imidacloprid + Permethrin combinations (as used in Assurity Plus):

• Flea Control Efficacy:
  • Achieves 95–100% flea mortality within 12 to 24 hours of application.
  • Maintains >95% effectiveness against new infestations for up to 4 weeks.
• Tick Repellency and Killing Power:
  • Begins repelling ticks within 2–4 hours of exposure.
  • Kills Rhipicephalus sanguineus, Dermacentor variabilis, and Ixodes ricinus species effectively.
  • Prevents tick attachment by over 90% within 48 hours, reducing pathogen transmission.
• Lice Eradication:
  • Rapidly kills Trichodectes canis (biting lice) within 48 hours.
  • Prevents re-infestation with monthly reapplication

Conclusion

Assurity Plus Spot On 4.0 ml for Dogs is a trusted, effective, and convenient solution for controlling parasites in large dogs. With monthly application, pet parents can ensure lasting protection and peace of mind. As always, consult your veterinarian before starting any parasite control regimen. Assurity Plus Spot On 4.0 ml for Dogs offers a powerful, reliable, and veterinarian-recommended solution for protecting large breed dogs from external parasites such as fleas, ticks, and lice. Its unique combination of Imidacloprid and Permethrin delivers rapid killing action, long-lasting repellency, and a month-long shield against re-infestation—helping to prevent both irritation and vector-borne diseases.