Pendistrin-SH 6 mL Ear Drops for Dogs – Dosage and Safety Explained

Ear infections are among the most common reasons for veterinary visits in dogs. Fortunately, products like Pendistrin-SH 6 mL offer a potent and effective treatment option. A combination ear drop solution with antibacterial and anti-inflammatory properties, Pendistrin-SH is a veterinary favorite for treating ear infections in dogs.

What is Pendistrin-SH 6 mL?

Pendistrin-SH is a veterinary ear drop solution designed to treat bacterial ear infections and inflammatory ear conditions in dogs. It comes in a 6 mL dropper bottle, ideal for administering precise doses directly into the ear canal.

Key Properties:

• Antibacterial
• Anti-inflammatory
• Topical action
• Formulated for external ear infections

Indications: What is Pendistrin-SH 6 mL Used For in Dogs?

Pendistrin-SH is indicated for the topical treatment of canine otitis externa and associated bacterial, fungal, or yeast infections.

Primary Indications:

1. Allergic Ear Infections
   Where inflammation and secondary infections occur.
2. Moist Ears After Bathing or Swimming
   Prevents the development of infections due to retained moisture.
3. Post-Surgical Infections or Preventive Use
   Especially after ear procedures to prevent microbial colonization.
4. Ear Mites (secondary infection)
   Often paired with mite treatments where secondary bacterial infection is present.

Why Use Pendistrin-SH?

Ear infections can cause significant distress in dogs. Symptoms include:

• Persistent scratching
• Head shaking
• Ear discharge (yellow, brown, or bloody)
• Foul smell
• Redness or swelling

Pendistrin-SH 6 mL is ideal because:

• It reduces inflammation and pain (Hydrocortisone, Lignocaine)
• It targets bacteria like Staphylococcus, Pseudomonas, Proteus (Gentamicin)
• It helps eliminate fungi and yeast (Clotrimazole)

Dosage Guidelines and Administration of Pendistrin-SH 6 mL for Dogs

Correct dosage and proper administration of Pendistrin-SH are essential to ensure the effective treatment of ear infections and to minimize the risk of side effects. This section provides a comprehensive guide on how to dose and apply Pendistrin-SH safely and effectively.

Dosage Guidelines

The dosage of Pendistrin-SH depends on the dog’s size, severity of the ear infection, and veterinarian’s recommendation. The following table provides general dosage guidance:

Note: Always adhere to your veterinarian’s specific dosage instructions, as individual cases may require dose adjustments.

How to Administer Pendistrin-SH 6 mL

Proper application technique improves treatment success and ensures the medication reaches the site of infection effectively.

Step-by-Step Administration Guide

1. Prepare Your Dog:
   • Secure your dog in a comfortable position.
   • Gently restrain the head to prevent sudden movement.
2. Inspect and Clean the Ear:
   • Examine the ear canal for debris, discharge, or excessive wax.
   • Clean the ear gently using a veterinary-approved ear cleaner if necessary.
   • Avoid using cotton swabs that can damage the ear canal or push debris further inside.
3. Shake the Bottle:
   • Shake the Pendistrin-SH bottle well to ensure uniform distribution of ingredients.
4. Massage the Ear:
   • This encourages the drops to reach deep inside the ear canal.
5. Allow Time for Absorption:
   • Prevent the dog from shaking its head immediately after application for at least a few minutes.
   • This helps keep the medication inside the ear canal for maximum effect.
6. Repeat for the Other Ear:
   • If both ears are infected, repeat the procedure on the other ear using the same care.

Additional Tips for Effective Administration

• Use Consistently: Administer the medication at the same times each day to maintain steady therapeutic levels.
• Monitor Your Dog: Watch for signs of improvement or adverse reactions.
• Complete Full Course: Do not stop treatment prematurely, even if symptoms improve, to prevent recurrence.
• Consult the Vet: If symptoms persist beyond the treatment period or worsen, consult your veterinarian for reassessment.

When to Avoid Administration

• Do not apply if the eardrum is suspected to be perforated.
• Avoid use if your dog is experiencing severe pain or bleeding in the ear canal without veterinary advice.
• If your dog shows an allergic reaction after the first application, discontinue use and contact your vet immediately.

Precautionary Guidelines and Contraindications of Pendistrin-SH for Canine Use                                                                                                                              

Pendistrin-SH is generally safe and effective when used correctly, but like all medications, it requires responsible use to avoid adverse effects and complications.

Safety Information

• Veterinary Guidance Required: Always use Pendistrin-SH after a proper veterinary diagnosis. Ear infections can have various causes, and inappropriate treatment can worsen the condition.
• Do Not Use in Dogs With a Ruptured Eardrum: If the eardrum (tympanic membrane) is damaged or perforated, the medication could enter the middle or inner ear, potentially causing toxicity or more serious issues.
• Avoid Contact With Eyes and Mucous Membranes: The ingredients in Pendistrin-SH are for topical ear use only and can irritate the eyes, nose, or mouth if accidentally contacted.
• Avoid Overuse: Follow the prescribed dosage strictly. Overuse of antibiotics like gentamicin can lead to resistance and reduced effectiveness.
• Not for Systemic Infections: Pendistrin-SH is formulated for topical use in the ear canal and should not be used to treat infections elsewhere in the body.
• Use Caution in Pregnant or Lactating Dogs: Safety in pregnant or nursing dogs has not been fully established; only use under strict veterinary supervision.
• Store Properly: Keep the bottle tightly closed, away from sunlight and out of reach of children or other animals.

Precautions

• Clean the Ear Canal Before Use: Excess wax, debris, or discharge should be gently cleaned before application to improve medicine contact with the affected area.
• Monitor for Improvement: If symptoms worsen or do not improve within 7 days, contact your veterinarian as this may indicate resistant infection or other complications.
• Avoid Simultaneous Use with Other Ear Medications: Using multiple ear treatments concurrently without veterinary advice can cause interactions or excessive irritation.
• Observe for Allergic Reactions: Watch for signs like swelling, hives, or increased itching, which may require immediate medical attention.

Contraindications

Pendistrin-SH should not be used in the following cases:

• Hypersensitivity: Dogs with known allergy to any components of Pendistrin-SH (gentamicin, hydrocortisone, clotrimazole, or lignocaine) should avoid this medication.
• Perforated Eardrum: If the tympanic membrane is ruptured or suspected to be damaged, topical use is contraindicated.
• Deep Ear Infections or Otitis Interna: The medication is designed for the external ear canal and may be ineffective or harmful if the infection is deeper.
• Severe Ear Trauma or Ulceration: Avoid use if the ear canal skin is severely damaged or ulcerated without veterinary clearance.

Possible Side Effects of Pendistrin-SH 6 mL in Dogs

Pendistrin-SH is well tolerated in most dogs, but some side effects can occur.

Common (Mild) Side Effects:

• Mild Irritation or Redness: Temporary discomfort, itching, or slight redness inside the ear may occur shortly after application.
• Increased Ear Discharge: Some dogs may experience a transient increase in discharge as the infection starts to clear.
• Head Shaking or Scratching: Occasional increased scratching or shaking of the head might occur initially due to relief of discomfort.

Less Common (Moderate) Side Effects:

• Allergic Reactions: Some dogs might develop swelling, rash, or hives around the ear or on other parts of the body.
• Ear Canal Dryness or Flaking: Prolonged use can sometimes lead to dryness or mild flaking of the ear skin.

Rare but Serious Side Effects:

• Vestibular Signs: Signs such as head tilt, loss of balance, or nausea may indicate inner ear irritation.
• Severe Allergic Reactions: Difficulty breathing, severe swelling, or collapse are emergencies requiring immediate veterinary care.

What to Do if Side Effects Occur

• Mild Side Effects: Usually resolve without intervention. Continue treatment and monitor.
• Persistent or Worsening Symptoms: Contact your veterinarian promptly.
• Severe Reactions: Stop the medication immediately and seek emergency veterinary attention.

Scientific Research Behind Pendistrin-SH 6 mL for Dogs

These ingredients have each been extensively studied in veterinary medicine, especially in the management of canine otitis externa—a common condition caused by bacteria, fungi, and inflammation.

Below is a breakdown of the scientific evidence supporting each component of Pendistrin-SH and their synergistic use.

1. Gentamicin Sulphate – Broad-Spectrum Antibiotic

Gentamicin is an aminoglycoside antibiotic effective against Gram-negative and some Gram-positive bacteria.

 Scientific Studies:

• Patel et al. (2016), Vet Microbiol Journal:
  Found Gentamicin to be highly effective in resolving Pseudomonas aeruginosa and Staphylococcus intermedius infections in canine ears.
• Zoran et al. (2001), J Am Vet Med Assoc (JAVMA):
  Showed that topical gentamicin significantly reduced microbial load in dogs with chronic otitis within 7–10 days of treatment.

Key Benefits in Pendistrin-SH:

• Treats bacterial ear infections
• Reduces pathogen load quickly
• Works locally with minimal systemic absorption

2. Clotrimazole – Potent Antifungal Agent

Scientific Studies:

• Bond et al. (1998), Vet Dermatology:
  Reported that Clotrimazole is extremely effective against Malassezia pachydermatis—a leading cause of fungal otitis in dogs.
• Scott DW et al., (2001), Small Animal Dermatology:
  Documented successful resolution of otitis externa in over 90% of canine cases treated with topical clotrimazole formulations.

Key Benefits in Pendistrin-SH:

• Controls fungal and yeast infections
• Effective against Malassezia and Candida
• Enhances results when combined with antibiotics

3. Hydrocortisone – Anti-inflammatory Corticosteroid

Hydrocortisone is a mild glucocorticoid steroid that suppresses local inflammation, reduces redness, swelling, and relieves itching.

Scientific Studies:

• Wagner & Roth (2000), Vet Med Review:
  Hydrocortisone demonstrated rapid anti-inflammatory effects and helped in restoring the ear canal epithelium faster when used with antimicrobials.
• Kwochka KW et al., (1994), Vet Dermatol:
  Clinical trials confirmed that anti-inflammatory ear drops containing hydrocortisone significantly shortened healing time in dogs with allergic and infectious otitis.

Key Benefits in Pendistrin-SH:

• Reduces swelling and pain
• Improves comfort and compliance
• Enhances penetration of antibiotics

Veterinary Consensus:

Multi-drug formulations provide superior outcomes in polymicrobial infections compared to single-agent therapies.

Conclusion

Pendistrin-SH 6 mL for dogs is a trusted, multi-action treatment for ear infections caused by bacteria and fungi. With its combination of antibiotic, antifungal, anti-inflammatory, and anesthetic properties, it provides fast, effective relief while promoting healing in the delicate ear canal.Always use under veterinary supervision, and follow dosage and safety guidelines for optimal results.