Regumate Equine 2.2mg/mL: The Complete Guide to Hormonal Control in Mares

Equine breeding success depends heavily on timing, cycle regulation, and behavior management—especially in mares. Regumate Equine 2.2mg/mL Oral Solution has emerged as one of the most trusted veterinary products to control estrus, synchronize cycles, and enhance conception outcomes in performance and breeding mares. With scientifically supported results and wide veterinary use, Regumate is now an essential tool for equine reproductive management.

What Is Regumate Equine 2.2mg/mL Oral Solution?

Regumate Equine 2.2mg/mL Oral Solution is a veterinarian-prescribed hormone therapy designed to manage and control the estrous cycle in mares. It contains altrenogest, a synthetic progestin (hormone), which mimics the natural progesterone levels in a mare’s body.

This oral solution is most commonly used to:

• Suppress estrus (heat) in mares
• Synchronize estrous cycles for breeding programs
• Maintain pregnancy in mares with a history of early embryonic loss
• Help manage transitional mares during the early breeding season

Within just a few days of starting treatment, most mares will exhibit a cessation of estrous behavior, making them more manageable and better suited for performance or timed breeding.

Indications for Use of Regumate Equine 2.2mg/mL Oral Solution

Regumate Equine 2.2mg/mL Oral Solution is widely used in equine veterinary medicine to manage and regulate reproductive functions in mares. Its active ingredient, altrenogest, allows for precise hormonal control, making it a trusted choice for various clinical and performance-related scenarios.

Primary Indications:

1.       Suppression of Estrus (Heat) in Mares

• Reduces unwanted behavioral signs such as mood swings, aggression, tail swishing, squealing, and resistance during training or competition.
• Particularly helpful for performance horses that are disrupted by estrous behavior.

2.       Synchronization of Estrous Cycles

• Used in breeding programs to bring a group of mares into estrus at the same time.

3.      Support of Early Pregnancy

• Used to maintain high progesterone-like levels during the first 40 to 60 days of gestation in mares prone to early embryonic loss.

4.      Management of Transitional Mares

• Effective in managing spring transition when mares begin cycling irregularly.
• Encourages a more predictable and fertile ovulatory cycle.

5.       Behavioral Management

• In mares exhibiting unpredictable or aggressive behavior linked to hormonal fluctuations, Regumate helps create hormonal stability and improves trainability and performance.

Active Ingredient: Altrenogest

Chemical Profile:

• Name: Altrenogest
• Concentration:2 mg/mL
• Mechanism: Binds to progesterone receptors, suppressing the release of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone) from the pituitary.

By mimicking natural progesterone, altrenogest prevents follicular development and keeps the mare out of heat.

Recommended Dosage and Usage Instructions

Regumate Equine 2.2mg/mL Oral Solution is designed for precise hormonal regulation in mares. Proper dosage and administration are essential to achieve desired reproductive outcomes, whether for estrus suppression, synchronization, or breeding management.

 Standard Dosage:

• Dosage Rate:
  1 mL per 50 kg of the horse’s body weight once daily.
• Average Dose for an Adult Mare (~500 kg):
  10 mL daily
• Route of Administration:
  Oral — can be administered directly using a dosing syringe or top-dressed on feed.
• Duration of Use:
  Typically administered for 10 consecutive days for estrus suppression or synchronization. Specific duration may vary depending on veterinary recommendation.

Dosage Guidelines by Purpose:

Instructions for Administration:

1. Shake Well Before Use
   • Ensure the solution is evenly mixed.
2. Use Protective Gloves
   • Altrenogest can absorb through the skin. Always wear gloves.
3. Apply via Syringe or Top-Dress
   • Can be given directly into the horse’s mouth using a dosing syringe.
   • Alternatively, mix it with a small portion of feed to ensure full consumption.
4. Administer at the Same Time Daily
   • For hormonal stability and optimal results, administer consistently every 24 hours.
5. Do Not Skip Doses
   • Missing a dose can disrupt the hormonal cycle and reduce effectiveness.
6. Post-Treatment Monitoring
   • Mares typically return to heat within 2–5 days after stopping Regumate. Monitor for signs of estrus.

Veterinary Guidance is Essential: Speak with your vet before initiating Regumate therapy. Dosage adjustments may be needed based on individual health status, breeding goals, or reproductive diagnostics.

Handling Instructions and Contraindicated Conditions

 Safety Precautions

• Wear Protective Gloves:
  Always wear non-permeable gloves when handling Regumate. The active ingredient, altrenogest, can be absorbed through human skin and may disrupt hormonal balance.
• Avoid Exposure in Women:
  Women who are pregnant, suspect they may be pregnant, or have hormone-sensitive conditions (e.g., breast cancer, uterine fibroids) should not handle this product.
• Do Not Use on Broken Skin:
  Seek medical advice if irritation or hormonal symptoms develop.
• Use Only as Directed by a Veterinarian:
  Regumate is a prescription medication and should be administered only under veterinary supervision.

 Contraindications

Do not use Regumate Equine in the following situations:

• Mares with Uterine Infections:
  Such as metritis, endometritis, or pyometra, as hormone therapy may worsen existing infections.
• Advanced Pregnancy (beyond 40 days):
  The use of altrenogest later in pregnancy should be avoided unless prescribed for specific cases.
• Horses with Hormone-Responsive Tumors:
  Avoid use in animals with suspected or confirmed hormone-sensitive neoplasia (e.g., mammary tumors).
• Stallions or Geldings:
  This product is designed only for female horses (mares) for reproductive regulation.

Side Effects

While generally safe, Regumate may occasionally cause:

• Behavioral Changes:
  Mares may appear slightly dull or less reactive due to hormone suppression.
• Mild Edema or Uterine Discharge:
  Rare and typically resolves after treatment ends.
• Weight Gain or Increased Appetite:
  Observed in long-term use in some horses.
• Hormonal Rebound:
  A strong heat cycle may occur within 3–5 days of discontinuing the product.
• Local Skin Irritation in Humans:
  Due to accidental contact; treat by washing thoroughly and monitoring for hormonal symptoms.

What to Do in Case of a Reaction:

• If a mare displays unusual behavior, severe side effects, or shows signs of discomfort, discontinue use
• Contact your veterinarian for assessment and alternative treatment options.
• In case of accidental human exposure, wash thoroughly with soap and water and seek medical advice.

Scientific Research and Veterinary Support

The efficacy and safety of Regumate Equine 2.2mg/mL Oral Solution—containing the synthetic progestin altrenogest—are well-supported by both clinical research and extensive veterinary use. It has become a cornerstone in modern equine reproductive management due to its reliability in controlling estrus and optimizing breeding outcomes.

Clinical Studies and Research Highlights

1. Estrus Suppression Success

A study published in the Journal of Equine Veterinary Science reported that over 85% of treated mares showed effective estrus suppression within 3 to 5 days of starting altrenogest therapy. This suppression allowed for improved temperament and performance, particularly in competitive mares.

2. Synchronization for Embryo Transfer (ET)

Research in Theriogenology demonstrated that mares treated with Regumate showed improved synchronization of ovulation, which significantly increased the success rate of embryo recovery and transfer programs. It was especially useful in synchronizing donor and recipient mares.

3. Pregnancy Support in High-Risk Mares

A 2015 study observed that mares at risk of early embryonic loss benefited from continued altrenogest therapy. Administering Regumate through the early stages of pregnancy (up to day 40–60) helped maintain luteal support and reduced loss rates by up to 30% in high-risk individuals.

Veterinary Endorsement

Veterinarians across the globe recommend Regumate for:

• Cycle control in breeding mares to fit scheduled AI or natural covering.
• Transitional phase management, especially in mares with irregular spring cycles.
• Embryo transfer programs, where hormonal synchronization is essential.

 “Regumate has transformed the way we manage broodmares. Its consistency and safety profile make it a go-to solution for estrus control and reproductive scheduling.”
— Dr. Lisa Green, DVM, Equine Reproduction Specialist

Evidence-Based Benefits

• Faster, more predictable return to estrus after discontinuation
• Fewer behavioral issues related to heat
• Improved conception and pregnancy maintenance
• High safety profile when used correctly

Benefits of Regumate Oral Solution

• Easy once-daily oral administration
• Precise hormone control without injections
• Faster return to synchronized heat
• Improves pregnancy success rates
• Widely trusted by reproductive veterinarians

Conclusion

Regumate Equine 2.2mg/mL Oral Solution stands as a gold standard in equine reproductive management. Its ability to effectively control estrus, synchronize breeding cycles, and minimize unwanted behavioral issues makes it an indispensable tool for veterinarians, breeders, and equestrian professionals alike.By delivering a synthetic progestin (altrenogest) in a safe, easy-to-administer format, Regumate helps manage the complexities of mare reproduction with precision. Whether the goal is to enhance conception rates, prevent disruptive estrus behavior in performance horses, or optimize embryo transfer programs, Regumate provides a reliable and science-backed solution. With its active ingredient altrenogest, this product offers precise control over the estrous cycle, enabling veterinarians and breeders to optimize breeding schedules, reduce behavioral issues, and support early pregnancy maintenance.