Complete Protection in One Tablet
Large dogs generally cost more to protect, because most owners end up buying a large spot-on, a large wormer and a separate heartworm preventive. Credelio Plus consolidates all three into one monthly chew containing lotilaner and milbemycin oxime.
Elanco introduced the combination to India recently, though lotilaner itself is well established internationally.
Parasites Covered
Fleas, ticks, heartworm (Dirofilaria immitis) prevention, roundworm, hookworm and whipworm.
Practical Notes for Owners
Give with food. Despite the higher active ingredient content, the tablet remains small relative to the dog, which helps with acceptance. Water exposure does not affect performance.
Specifications
| Specification | Detail |
|---|---|
| Active ingredients | Lotilaner 900 mg + Milbemycin oxime 33.75 mg |
| Dog weight range | 22–45 kg |
| Pack size | 3 chewable tablets |
| Form | Flavoured chewable tablet |
| Dosing frequency | One tablet monthly |
| Species | Dogs only |
| Manufacturer | Elanco |
Dosage & Administration
One chewable tablet by mouth per month, given with food. Match the tablet strength to the dog’s current weight. Maintain a consistent monthly dosing date. Test for existing heartworm infection before beginning heartworm prevention.
Dr. Moliya (DVM) to verify against the current pack insert before publication.
Safety Information & Warnings
- For dogs only. Do not give to cats.
- Give with food to ensure proper absorption.
- Test for existing heartworm infection before starting.
- Use with caution in dogs with a history of seizures.
- Dogs over 45 kg require a combination of tablets as directed by a veterinarian — do not guess.
- Refer to the product label and package insert before use.
Frequently Asked Questions
My dog weighs more than 45 kg. What do I use?
Your veterinarian will advise on combining tablets to reach the correct dose. Do not work this out yourself — the calculation needs to account for both active ingredients.
Is one tablet really enough for a large dog?
Yes. The 900 mg lotilaner and 33.75 mg milbemycin oxime content is calculated for the 22–45 kg range. The tablet is small but the dose is not.
How does it compare with NexGard Spectra?
Both are monthly chews covering fleas, ticks, heartworm and intestinal worms. NexGard Spectra additionally covers demodectic and sarcoptic mange mites. Your veterinarian can advise which suits your dog’s situation.
Does it cover tapeworm?
No. Roundworm, hookworm and whipworm only. Tapeworm requires a praziquantel product.
Can I give it at the same time each month?
Yes, and you should. A fixed monthly date is the simplest way to avoid gaps in heartworm cover.







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